Recent advances in understanding & managing male infertility
نویسندگان
چکیده
Male infertility remains a struggle to definitively diagnose and treat with many men labelled as "idiopathic infertility" and eventually requiring assisted reproductive techniques. Along those lines, research groups are continuing to explore current social and environmental factors, including the obesity epidemic, and their effects on male fertility potential. Novel biomarkers of natural fertility status and azoospermia etiology have additionally seen recent attention with ACRV1 and TEX101/ECM1 assays either currently or soon to be commercially available. Despite these advancements, however, medical treatment options have seen little progress. Though surgical therapies have similarly seen little transformation, groups are exploring the use of testicular sperm for couples with elevated sperm DNA fragmentation and either planned or previously failed IVF/ICSI. Concerted collaborative efforts will be needed as we move forward to better understand the challenges men face when struggling to conceive.
منابع مشابه
Investigating the Potential Role of piRNAs in Male Infertility
Infertility is a reproductive-related disorder and different factors account for its development. Male factors contribute to at least 20% of infertility. Despite the efforts performed in this field, the causes often remain idiopathic. Epigenetic factors such as small non-coding RNAs play important functions in male infertility. Also, P-element induced wimpy testis in drosophila-interacting RNAs...
متن کاملInfertility in male dogs: recent advances Infertilidade do macho canino: atualidades
Very little is known about male infertility in the dog. The causes of infertility are divided into two main groups, congenital infertility and acquired infertility. Congenital infertility is caused by genetic (chromosomal) abnormalities and is present at birth. Acquired infertility develops during the dog's lifetime. Infertility in male dogs is diagnosed by a good medical history, including bre...
متن کاملMicrodeletions on the long arm of the Y chromosome and their association with male-factor infertility.
Significant advances in treatment have enabled previously infertile males to achieve fatherhood, when only a few years ago they would have had no chance of biological paternity. In contrast to the overall success of assisted reproduction, the aetiology of male-factor infertility is poorly understood. Recent studies have shown, however, that a significant proportion of men with severe infertilit...
متن کاملA Critical Appraisal on the Role of Varicocele in Male Infertility
Varicocele is a major cause of male infertility, as it may impair spermatogenesis through several distinct physiopathological mechanisms. With the recent advances in biomolecular techniques and the development of novel sperm functional tests, it has been possible to better understand the mechanisms involved in testicular damage provoked by varicocele and, therefore, propose optimized ways to pr...
متن کاملThe genetic causes of male factor infertility: a review.
OBJECTIVE To illustrate the necessity for an enhanced understanding of the genetic basis of male factor infertility, to present a comprehensive synopsis of these genetic elements, and to review techniques being utilized to produce new insights in fertility research. BACKGROUND Male factor infertility is a complex disorder that affects a large sector of the population; however, many of its eti...
متن کامل